Nigeria and South Africa account for about a third of Africa’s economic might, and have led much of its peacemaking and peacekeeping initiatives over the last two and a half decades. Both account for at least 60 per cent of the economy of their respective sub-regions in West and Southern Africa. The success of political and economic integration in Africa thus rests heavily on the shoulders of these two regional powers who have both collaborated and competed with each other in a complex relationship that is Africa’s most indispensable. Nigeria remains among South Africa’s largest trading partners in Africa, while both countries have cooperated in building the institutions of the African Union (AU) and the New Partnership for Africa’s Development (NEPAD). Nigeria and South Africa have also sought to give Africa a stronger global voice, while competing as rivals on issues such as peacemaking in Cote d’Ivoire, Libya and Guinea-Bissau. While Nigeria is the most ethnically diverse country in Africa, South Africa is the most racially diverse state on the continent. Both countries have had a tremendous cultural impact on the continent in terms of Nollywood movies and South African soap operas. The first three chapters of this book assess Nigeria/South Africa relations in the areas of politics, economics and culture. The second section has three essays that examine the issue of hegemonic leadership in relation to Nigeria and South Africa. The third section consists of four essays on the contributions to the bilateral relationship and leadership roles of four prominent South Africans and Nigerians: Nelson Mandela, Thabo Mbeki, Olusegun Obasanjo and Sani Abacha. The final section of the book analyses three technocratic Nigerian and South African ‘visionaries’: Adebayo Adedeji, Nkosazana Dlamini-Zuma, and Ngozi Okonjo-Iweala.